Spythiakaran

Meaning: Crazy stalker.
Pronunciation: Spy-thee-ya-car-run.
Usage: If you don't have your share of spythiakarans, you've not made it as an item queen in Kollywood.
Root: Spy (covert watch) + Paithiakaran (tamil for crazy man).

Whovuzela

Meaning: One who keeps blowing his/her own trumpet.
Pronunciation: Who-woo-zay-la.
Usage: You can't be in show business if you're not a whovuzela.
Root: Who + Vuvuzela (the african horn that produces a loud monotone note).

Gaaji Mastan

Meaning: One who'll do anything for an extended batting session.
Pronunciation: Ga-jee-mus-thaan.
Usage: Chetan Chauhan and Anshuman Gaekwad are Gaaji Mastans of yore.
Root: Gaaji (a street cricket term in Chennai) + Haji Mastan (name of a bootlegger don)

Spillter Coffee

Meaning: What remains in the cup after spilling the coffee.
Pronunciation: Self explanatory.
Usage: Life is like spillter coffee. You have to get by with what is left over.
Root: Spill + Filter Coffee.

Chain Therapy

Meaning: Forming human networks and helping patients by using the power of many.
Pronunciation: Self explanatory.
Usage: Chain Therapy is the way forward for millions of poor people who cannot afford to pay their hospital bills.
Root: Chain (network) + Therapy (treatment of illness).
Note: The concept is already up and running here.